The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD).
Daniela Maria TănaseEvelina Maria GosavClaudia Florida CosteaManuela CiocoiuCristina Mihaela LacatusuMinela Aida MaranducaAnca OuatuMariana FloriaPublished in: Journal of diabetes research (2020)
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and intricate association is supported and mediated by insulin resistance (IR). In this review, we discuss the NAFLD immunopathogenesis, connection with IR and T2DM, the role of screening and noninvasive tools, and mostly the impact of the current antidiabetic drugs on steatosis liver and new potential therapeutic targets.
Keyphrases
- insulin resistance
- glycemic control
- type diabetes
- high fat diet
- adipose tissue
- metabolic syndrome
- end stage renal disease
- risk factors
- skeletal muscle
- high fat diet induced
- polycystic ovary syndrome
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- cardiovascular disease
- weight loss
- risk assessment
- climate change
- cardiovascular risk factors
- patient reported outcomes
- case control