Persistent 18F-FDG Brain PET Fronto-Temporal Hypometabolism and Cognitive Symptoms Two Years after SARS-CoV-2 Infection: A Case Report.
Stefania RossiElena ProdiRosalba MoreseGaetano PaoneTeresa RubertoLeonardo SaccoPublished in: Neurology international (2023)
At least 10% of patients experience persistent symptoms after SARS-CoV-2 infection, a condition referred to as post-acute COVID-19, post-acute sequelae of SARS-CoV-2 infection (PASC), long COVID, long-haul COVID, long-term effects of COVID, post-COVID-19 and chronic COVID. In this report, we describe a case of persistent cognitive deficits developed after SARS-CoV-2 infection in a 40-year-old woman with a family history of early-onset Alzheimer's disease (EOAD) since her father was diagnosed with EOAD at the age of 50. We describe the clinical picture and workup, with special emphasis on the alterations of brain glucose metabolism evidenced by 18-fluoro-deoxy-glucose positron emission tomography (FDG-PET), which could be considered a useful marker of the presence and persistence of cognitive deficits.
Keyphrases
- positron emission tomography
- coronavirus disease
- sars cov
- respiratory syndrome coronavirus
- computed tomography
- early onset
- pet ct
- pet imaging
- liver failure
- late onset
- drug induced
- intensive care unit
- end stage renal disease
- insulin resistance
- cognitive decline
- extracorporeal membrane oxygenation
- resting state
- patient reported outcomes
- depressive symptoms
- cerebral ischemia
- patient reported
- adipose tissue