C2C12 cell model: its role in understanding of insulin resistance at the molecular level and pharmaceutical development at the preclinical stage.
Chun Y WongHani-Al SalamiCrispin R DassPublished in: The Journal of pharmacy and pharmacology (2020)
The use of C2C12 myoblast cell line is meaningful in pharmaceutical and biomedical research due to their expression of GLUT-4 and other features that are representative to human skeletal muscle cells. With the use of the C2C12 cell model, the impact of drug delivery systems (nanoparticles and quantum dots) on skeletal muscle, as well as the relationship between exercise, pancreatic β-cells and endothelial cells, was discovered.
Keyphrases
- skeletal muscle
- insulin resistance
- endothelial cells
- induced apoptosis
- cell therapy
- cell cycle arrest
- quantum dots
- single cell
- endoplasmic reticulum stress
- type diabetes
- adipose tissue
- physical activity
- oxidative stress
- high intensity
- binding protein
- long non coding rna
- mesenchymal stem cells
- sensitive detection
- weight loss
- cell proliferation
- vascular endothelial growth factor
- pi k akt
- energy transfer