Pharmacological inhibition of the integrated stress response accelerates disease progression in an amyotrophic lateral sclerosis mouse model.

Elías MarlinMiguel ValenciaNuria PeregrínRoberto FerreroMaría Jesús NicolásRodrigo Vinueza-GavilanesAntonio Pineda-LucenaJulio ArtiedaMontserrat ArrasateTomás Aragón

Published in: British journal of pharmacology (2023)

mice. This study reveals that the ISR works as a neuroprotective pathway in ALS motor neurons and reveals the toxicity that eIF2B activators may display in ALS patients.

Keyphrases

amyotrophic lateral sclerosis
mouse model
end stage renal disease
chronic kidney disease
newly diagnosed
ejection fraction
spinal cord
peritoneal dialysis
oxidative stress
type diabetes
skeletal muscle