Vascular Function in Continuous Flow LVADs: Implications for Clinical Practice.
Fouad KhalilRabea AslehRadha Kanneganti PerueJean-Marc WeinsteinAdam SolomonBatya Betesh-AbayAlexandros BriasoulisHilmi AlnsasraPublished in: Biomedicines (2023)
Left ventricular assist devices (LVADs) have been increasingly used in patients with advanced heart failure, either as a destination therapy or as a bridge to heart transplant. Continuous flow (CF) LVADs have revolutionized advanced heart failure treatment. However, significant vascular pathology and complications have been linked to their use. While the newer CF-LVAD generations have led to a reduction in some vascular complications such as stroke, no major improvement was noticed in the rate of other vascular complications such as gastrointestinal bleeding. This review attempts to provide a comprehensive summary of the effects of CF-LVAD on vasculature, including pathophysiology, clinical implications, and future directions.
Keyphrases
- heart failure
- left ventricular
- cystic fibrosis
- atrial fibrillation
- clinical practice
- risk factors
- acute myocardial infarction
- cardiac resynchronization therapy
- mitral valve
- hypertrophic cardiomyopathy
- mesenchymal stem cells
- replacement therapy
- coronary artery disease
- bone marrow
- acute coronary syndrome
- current status
- left atrial