Optimizing the Synthesis of Core/shell Structure Au@Cu2S Nanocrystals as Contrast-enhanced for Bioimaging Detection.
Liwei LiuSiyi HuYue WangShaozhuang YangJunle QuPublished in: Scientific reports (2018)
In this paper, we reported Au@Cu2S nanocrystals in the aqueous phase with a core/shell structure and dBSA encapsulation. The dBSA-Au@Cu2S crystals formed with an average size of approximately 9 nm. There was a strong absorption in the near-infrared (NIR) field located at 1348 nm, and they exhibited low toxicity in the in vitro tests. Furthermore, we demonstrated that dBSA-Au@Cu2S could be used for optical coherence tomography (OCT). The in vivo experimental results show that the OCT signal increased as the concentration of nanocrystals increased. In this research, we revealed that these core/shell-structured nanocrystals along with their low toxicity and excellent biocompatibility could be a valuable tool for current and future contrast-enhanced in vivo studies.
Keyphrases
- contrast enhanced
- room temperature
- optical coherence tomography
- magnetic resonance imaging
- diffusion weighted
- sensitive detection
- computed tomography
- magnetic resonance
- energy transfer
- reduced graphene oxide
- diffusion weighted imaging
- photodynamic therapy
- aqueous solution
- diabetic retinopathy
- quantum dots
- metal organic framework
- oxidative stress
- ionic liquid
- loop mediated isothermal amplification
- fluorescent probe
- dual energy
- living cells
- current status
- gold nanoparticles
- fluorescence imaging