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Anlotinib Inhibiting Mantle Cell Lymphoma Proliferation and Inducing Apoptosis through PI3K/AKT/mTOR Pathway.
Jiaping Wang
Zhijuan Xu
Yanli Lai
Yanli Zhang
Ping Zhang
Qitian Mu
Shujun Yang
Lixia Sheng
Guifang Ouyang
Published in:
Current molecular medicine (2024)
Anlotinib effectively inhibits proliferation and induces apoptosis in MCL both in vitro and in vivo. This inhibition is likely linked to suppressing phosphorylation in the PI3K/Akt/mTOR pathway.
Keyphrases
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signaling pathway
oxidative stress
cell death
cell cycle arrest
pi k akt
protein kinase