Circ_0004087 interaction with SND1 promotes docetaxel resistance in prostate cancer by boosting the mitosis error correction mechanism.

Liang ChenYarong SongTeng HouXuexiang LiLulin ChengYunxue LiYifei Xing

Published in: Journal of experimental & clinical cancer research : CR (2022)

Our study uncovered the crucial role of circ_0004087/SND1/MYB/BUB1 axis in modulating the error mitosis correction mechanism and DTX chemoresistance, suggesting that circ_0004087 may serve as a valuable prognostic biomarker and a potential therapeutic target in DTX-resistant PCa patients.

Keyphrases

prostate cancer
end stage renal disease
ejection fraction
newly diagnosed
transcription factor
radical prostatectomy
peritoneal dialysis
prognostic factors
risk assessment