Clinical relevance of gene expression in localized and metastatic prostate cancer exemplified by FABP5.

K NitschkeP ErbenF WaldbilligA AbdelhadiC-A WeisM GottschaltS WahbyP NuhnM BoutrosM S MichelJ von HardenbergThomas Stefan Worst

Published in: World journal of urology (2019)

FABP5 overexpression is frequent in PCa, but seems to be restricted to TMPRESS2:ERG fusion-negative tumors and is associated with SPOP and FOXA1 mutations. FABP5 overexpression appears to be indicative for increased activity in PPAR signaling, which is potentially druggable.

Keyphrases

binding protein
prostate cancer
gene expression
cell proliferation
squamous cell carcinoma
transcription factor
small cell lung cancer
radical prostatectomy
dna methylation
insulin resistance
type diabetes