Investigating the Relationship Between IGF-I, IGF-II, and IGFBP-3 Concentrations and Later-Life Cognition and Brain Volume.

Antoine Salzmann Sarah-Naomi JamesDylan M WilliamsMarcus Richards Dorina Cadar Jonathan M Schott William CoathCarole H SudreNishi Chaturvedi Victoria Garfield

Published in: The Journal of clinical endocrinology and metabolism (2021)

Increased measure in IIS parameters (IGF-I, IGF-II, and IGFBP-3) relate to better cognitive state in later life. There were apparent associations with specific cognitive domains (IGF-II relating to memory; IGFBP-3 relating to memory, processing speed, and WMHV; and IGF-I/IGFBP-3 molar ratio related to slower processing speed). IGFs and IGFBP-3 are associated with favorable cognitive function outcomes.

Keyphrases

pi k akt
binding protein
growth hormone
white matter
working memory
signaling pathway
type diabetes
magnetic resonance imaging
mild cognitive impairment
computed tomography
functional connectivity
resting state