MRI-Based Digital Models Forecast Patient-Specific Treatment Responses to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer.
Chengyue WuAngela M JarrettZijian ZhouNabil ElshafeeyBeatriz E AdradaRosalind P CandelariaRania M M MohamedMedine BogeLei HuoJason B WhiteDebasish TripathyVicente ValeroJennifer K LittonClinton YamJong Bum SonJingfei MaGaiane M RauchThomas E YankeelovPublished in: Cancer research (2022)
Integrating MRI data with biologically based mathematical modeling successfully predicts breast cancer response to chemotherapy, suggesting digital twins could facilitate a paradigm shift from simply assessing response to predicting and optimizing therapeutic efficacy.