Severe manifestations of SARS-CoV-2 in children and adolescents: from COVID-19 pneumonia to multisystem inflammatory syndrome: a multicentre study in pediatric intensive care units in Spain.
Alberto García-SalidoJuan Carlos de Carlos VicenteSylvia Belda HofheinzJoan Balcells RamírezMaría Slöcker BarrioInés Leóz GordilloAlexandra Hernández YusteCarmina Guitart PardellansMaite Cuervas-Mons TejedorBeatriz Huidobro LabargaJosé Luís Vázquez MartínezMíriam Gutiérrez JimenoIgnacio Oulego-ErrózJavier Trastoy QuintelaCarmen Medina MonzónLaura Medina RamosMaría Soledad Holanda PeñaJavier Gil-AntónClara Sorribes OrtíJosé Carlos Flores GonzálezRosa María Hernández PalomoInma Sánchez GanforninaEmilia Fernández RomeroMaría García-BesteiroJesús López-Herce CidRafael González Cortésnull nullPublished in: Critical care (London, England) (2020)
MIS-C seems to be the most frequent presentation among critically ill children with SARS-CoV-2 infection. MIS-C patients are older and usually healthy. They show a higher prevalence of gastrointestinal symptoms and shock and are more likely to receive vasoactive drugs and immunomodulators and less likely to need mechanical ventilation than non-MIS-C patients.