Alterations of plasma exosomal proteins and motabolies are associated with the progression of castration-resistant prostate cancer.
Pengyu LiuWenxuan WangFei WangJiaqi FanJinan GuoTao WuDongliang LuQingchun ZhouZhuohao LiuYuliang WangZhiqun ShangFranky Leung ChanWei YangXin LiShan-Chao ZhaoQingyou ZhengFei WangDinglan WuPublished in: Journal of translational medicine (2023)
Integration of proteomics and metabolomics data generated proteomic and metabolic signatures of plasma exosomes that may facilitate discrimination of CRPC from PCa and TFC patients, suggesting the potential of exosomal proteins and metabolites as CRPC markers. The study also confirmed the important role of exosomal protein LRG1 in PCa malignant progression.
Keyphrases
- end stage renal disease
- mass spectrometry
- ejection fraction
- newly diagnosed
- stem cells
- mesenchymal stem cells
- prognostic factors
- ms ms
- peritoneal dialysis
- machine learning
- dna methylation
- genome wide
- risk assessment
- bone marrow
- patient reported outcomes
- deep learning
- artificial intelligence
- amino acid
- patient reported