Shikonin attenuates rheumatoid arthritis by targeting SOCS1/JAK/STAT signaling pathway of fibroblast like synoviocytes.
Lianhua HeHuijie LuanJuan HeMiaomiao ZhangQingxia QinYiping HuYueming CaiDesheng SunYu ShiQingwen WangPublished in: Chinese medicine (2021)
Shikonin represents a promising new anti-rheumatoid arthritis drug candidate that has anti-synovitis effect in collagen induced arthritis mice and inhibits tumor necrosis factor-α-induced fibroblast like synoviocytes by targeting suppressor of cytokine signaling 1/ Janus kinase/signal transducer andactivator of transcription signaling pathway. These findings demonstrate that shikonin has anti-synovitis effect and has great potential to be a new drug for the treatment of rheumatoid arthritis.
Keyphrases
- rheumatoid arthritis
- signaling pathway
- disease activity
- high glucose
- drug induced
- ankylosing spondylitis
- interstitial lung disease
- diabetic rats
- pi k akt
- epithelial mesenchymal transition
- endothelial cells
- transcription factor
- induced apoptosis
- type diabetes
- cell proliferation
- adipose tissue
- metabolic syndrome
- insulin resistance
- skeletal muscle
- protein kinase
- high fat diet induced
- endoplasmic reticulum stress