Unusual hard metal lung disease: bronchiolocentric interstitial pneumonia.
Jen-Yu HsuF-Y ChuP-H WangM-L WuPublished in: Occupational medicine (Oxford, England) (2024)
A 38-year-old woman experienced a persistent dry cough and progressively worsening dyspnoea for 2 years. Spirometry testing revealed a moderate-to-severe restrictive abnormality. High-resolution chest computed tomography showed diffuse reticulonodular opacities. A lung biopsy disclosed alveolar parenchymal inflammation and fibrosis with bronchiolocentric features, prompting consideration of interstitial pneumonia. Following a thorough investigation of her occupational history and an on-site inspection, it was discovered that the patient had been grinding drill bits designed for printed circuit boards for 8 years, exposing her to hard metals. Mineralogical analyses confirmed excessive tungsten in urine, serum and hair, leading to a diagnosis of hard metal lung disease due to tungsten carbide-cobalt exposure. After discontinuing exposure and commencing corticosteroid therapy, her symptoms, pulmonary function and imaging showed modest improvement. This case highlights the significance of assessing occupational history in patients with interstitial pneumonia and understanding industrial hazards for accurate diagnosis and care.
Keyphrases
- cystic fibrosis
- high resolution
- lung function
- computed tomography
- oxidative stress
- healthcare
- community acquired pneumonia
- palliative care
- mass spectrometry
- positron emission tomography
- respiratory failure
- wastewater treatment
- heavy metals
- early onset
- weight gain
- case report
- quality improvement
- magnetic resonance
- low grade
- pain management
- stem cells
- photodynamic therapy
- cell therapy
- sleep quality
- fine needle aspiration
- acute respiratory distress syndrome
- reduced graphene oxide
- low cost
- mechanical ventilation