Clinical presentation of early syphilis and genomic sequences of Treponema pallidum strains in patient specimens and isolates obtained by rabbit inoculation.
Ligang YangXiaohui ZhangWentao ChenArlene C SeñaHeping ZhengYinbo JiangPei-Zhen ZhaoRongyi ChenLiuyuan WangWujian KeJuan C SalazarJonathan B ParrJoseph D TuckerKelly L HawleyMelissa J CaimanoChristopher M HennellyFarhang AghakanianEverton B BettinFeifei ZhangJane S ChenM Anthony MoodyJustin D RadolfBin YangPublished in: The Journal of infectious diseases (2024)
Our TPA detection rate was high from PS ulcer exudates and SS skin biopsies and over 50% from SS blood, with TPA isolation in over two-thirds of samples. Our results support the use of WGS from rabbit isolates to inform vaccine development.