Heterogeneous BCR-ABL1 signal patterns identified by fluorescence in situ hybridization are associated with leukemic clonal evolution and poorer prognosis in BCR-ABL1 positive leukemia.
Zhanglin ZhangZhiwei ChenMei JiangShuyuan LiuYang GuoLagen WanFei LiPublished in: BMC cancer (2019)
Our data showed that complex BCR-ABL1 signal patterns were associated with leukemic clonal evolution and poorer prognosis in BCR-ABL1 positive leukemia. Monitoring BCR-ABL1 signal patterns might be an effective means to provide prognostic guidance and treatment choices for these patients.
Keyphrases
- chronic myeloid leukemia
- tyrosine kinase
- acute myeloid leukemia
- end stage renal disease
- bone marrow
- newly diagnosed
- chronic kidney disease
- ejection fraction
- peritoneal dialysis
- prognostic factors
- electronic health record
- machine learning
- patient reported outcomes
- artificial intelligence
- deep learning
- energy transfer