CEACAM6 Promotes Lung Metastasis via Enhancing Proliferation, Migration and Suppressing Apoptosis of Prostate Cancer Cells.

Alireza SarajiKatharina WulfJanine Stegmann-FrehseDuan KangAnne OffermannGevorg ShaghoyanDanny JonigkMark Philipp KühnelSven PernerJutta KirfelVerena Sailer

Published in: Cancer genomics & proteomics (2024)

Functional validation revealed that CEACAM6 might play an important role in fostering metastatic spread to the lung of PCa patients via enhancing proliferation, migration and suppressing apoptosis in PC-3 and LNCaP cells. CEACAM6 might pose an attractive therapeutic target to prevent metastatic disease.

Keyphrases

cell cycle arrest
signaling pathway
induced apoptosis
pi k akt
endoplasmic reticulum stress
cell death
oxidative stress
squamous cell carcinoma
end stage renal disease
small cell lung cancer
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
single cell