A20 regulates the therapeutic effect of anti-PD-1 immunotherapy in melanoma.
Weinan GuoJinyuan MaSen GuoHuina WangSijia WangQiong ShiLin LiuTao ZhaoFengfan YangShuyang ChenJianru ChenJianhong ZhaoChen YuXiuli YiYuqi YangJingjing MaQingrong NiGuannan ZhuTianwen GaoChunying LiPublished in: Journal for immunotherapy of cancer (2021)
Together, our findings uncover a novel crosstalk between inflammatory molecules and antitumor immunity in melanoma, and highlight that A20 can be exploited as a promising target to bring clinical benefit to melanomas refractory to immune checkpoint blockade.
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