Pravastatin suppresses inflammatory cytokines and endothelial activation in patients at risk of developing preeclampsia: INOVASIA study.

Muhammad Ilham Aldika AkbarAngelina YosediputraRaditya Ery PratamaNur Lailatul FadhilahSulistyowati SulistyowatiFariska Zata AmaniErry Gumilar DachlanMuhammad Dikman AngsarGustaaf Albert Dekker

Published in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2021)

Administration of 40 mg pravastatin resulted in an improvement in NO levels, and a decrease in IL-6 and endothelin (ET-1) levels. The direction of the effect of pravastatin on these biomarkers appears to underpin the potential for a beneficial effect of pravastatin in the prevention of preeclampsia.

Keyphrases

early onset
endothelial cells
pregnancy outcomes
risk assessment
human health