Unraveling the Enigma of Organismal Death: Insights, Implications, and Unexplored Frontiers.

Peter B NobleAlexander PozhitkovKanhaiya SinghErik WoodsChunyu LiuMichael LevinGulnaz T JavanJun WanAhmed Safwat AbouhashemShomita S Mathew-SteinerChandan K Sen

Published in: Physiology (Bethesda, Md.) (2024)

Significant knowledge gaps exist regarding the responses of cells, tissues, and organs to organismal death. Examining the survival mechanisms influenced by metabolism and environment, this research has the potential to transform regenerative medicine, redefine legal death, and provide insights into life's physiological limits, paralleling inquiries in embryogenesis.

Keyphrases

induced apoptosis
healthcare
gene expression
cell cycle arrest
transcription factor
cell death
oxidative stress
climate change
endoplasmic reticulum stress
signaling pathway
risk assessment
free survival