Identification and validation of microtubule depolymerizing agent, CYT997, as a potential drug candidate for hepatocellular carcinoma.

Faiz AhmadLi MaWei WeiYi LiuIsaac HakimAaron DaughertySana MujahidAndrew A RadinMei-Sze ChuaSamuel So

Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)

CYT997 is a potentially efficacious and non-toxic drug candidate for HCC therapy. Its ability to down-regulate GPC3, β-catenin, and c-Myc highlights a novel mechanism of action.

Keyphrases

epithelial mesenchymal transition
cell proliferation
adverse drug
stem cells
risk assessment
mesenchymal stem cells
signaling pathway
electronic health record