Protease signaling through protease activated receptor 1 mediate nerve activation by mucosal supernatants from irritable bowel syndrome but not from ulcerative colitis patients.

Sabine BuhnerHannes HahneKerstin HartwigQin LiSheila VignaliDaniela OstertagChen MengGabriele HörmannspergerBreg BraakChristian PehlThomas FrielingGiovanni BarbaraRoberto De GiorgioIhsan Ekin DemirGüralp Onur CeyhanFlorian ZellerGuy BoeckxstaensDirk HallerBernhard KusterMichael Schemann

Published in: PloS one (2018)

Proteases in IBS and UC supernatants were responsible for nerve activation. Our data demonstrate that proteases, particularly those signalling through neuronal PAR1, are biomarker candidates for IBS, and protease profiling may be used to characterise IBS.

Keyphrases

irritable bowel syndrome
ulcerative colitis
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
electronic health record
big data
machine learning
deep learning
patient reported