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Spermidine-enhanced autophagic flux improves cardiac dysfunction following myocardial infarction by targeting the AMPK/mTOR signalling pathway.

Jing YanJian-Yun YanYu-Xi WangYuan-Na LingXu-Dong SongSi-Yi WangHai-Qiong LiuQi-Cai LiuYa ZhangPing-Zhen YangXian-Bao WangAi-Hua Chen
Published in: British journal of pharmacology (2019)
Our findings suggest that spermidine improved MI-induced cardiac dysfunction by promoting AMPK/mTOR-mediated autophagic flux.
Keyphrases
  • left ventricular
  • cell death
  • oxidative stress
  • skeletal muscle
  • cell proliferation
  • heart failure
  • diabetic rats
  • high glucose
  • protein kinase
  • drug induced
  • atrial fibrillation
  • stress induced