Natural Coevolution of Tumor and Immunoenvironment in Glioblastoma.
Lingxiang WuWei WuJunxia ZhangZheng ZhaoLiangyu LiMengyan ZhuMin WuFan WuFengqi ZhouYuxin DuRui-Chao ChaiWei ZhangXiaoguang QiuQuanzhong LiuZiyu WangJie LiKening LiApeng ChenYinan JiangXiangwei XiaoHan ZouRashmi SrivastavaTingting ZhangYun CaiYuan LiangBin HuangRuohan ZhangFan LinLang HuXiuxing WangXu QianSali LvBaoli HuSiyuan ZhengZhi-Bin HuHongbing ShenYongping YouRoel G W VerhaakTao JiangQiang-Hu WangPublished in: Cancer discovery (2022)
GBM progression could be induced by hypoxia via the HIF1A-FOSL2 axis. Tumor-derived ANXA1 is associated with recruitment and polarization of bone marrow-derived macrophages to suppress the immunoenvironment. The polarized macrophages promote tumor cell NES transition and migration. This article is highlighted in the In This Issue feature, p. 2711.