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Neural correlates of anxious distress in depression: A neuroimaging study of reactivity to emotional faces and resting-state functional connectivity.

Laura NawjinRichard DingaMoji AghajaniMarie-José van TolNic J A van der WeeAndreas WunderDick J VeltmanBrenda W H J Penninx
Published in: Depression and anxiety (2022)
Current findings suggest that amygdala and striato-limbic hyperactivity to emotional faces may be a neurobiological hallmark specific to MDD with anxious distress, relative to MDD without anxious distress. This may provide preliminary indications of the underlying mechanisms of anxious distress in depression, and underline the importance to account for heterogeneity in depression research.
Keyphrases
  • functional connectivity
  • resting state
  • depressive symptoms
  • major depressive disorder
  • sleep quality
  • bipolar disorder