Interferon-stimulated gene PVRL4 broadly suppresses viral entry by inhibiting viral-cellular membrane fusion.

Qiaomei CaiNina SunYurui ZhangJingfeng WangChaohu PanYu ChenLili LiXiaorong LiWancheng LiuSaba R AliyariGenhong ChengGenhong Cheng

Published in: Cell & bioscience (2024)

Overall, our studies not only identify PVRL4 as an intrinsic broad-spectrum antiviral ISG, but also provide a candidate host-directed target for antiviral therapy against various viruses including SARS-CoV-2 and its variants in the future.

Keyphrases

sars cov
copy number
signaling pathway
respiratory syndrome coronavirus
dendritic cells
genome wide
current status
stem cells
dna methylation
genome wide identification
cell therapy
immune response
transcription factor