Mapping pediatric brain tumors to their origins in the developing cerebellum.
Konstantin OkonechnikovPiyush JoshiMari SeppKevin LeissIoannis SarropoulosFlorent MuratMartin SillPengbo BeckKenneth Chun-Ho ChanAndrey KorshunovFelix SahmMaximilian Y DengDominik SturmJohn DeSistoAndrew M DonsonNicholas K ForemanAdam L GreenGiles RobinsonBrent A OrrQingsong GaoEmily DarrowJennifer L HadleyPaul A NorthcottJohannes GojoDaisuke KawauchiVolker HovestadtMariella G FilbinAndreas von DeimlingMarc ZuckermannKristian W PajtlerMarcel KoolDavid T W JonesNatalie JägerLena M KutscherHenrik KaessmannStefan M PfisterPublished in: Neuro-oncology (2023)
Based on our results, individual cells within a tumor may resemble different cell types along a restricted developmental lineage. Therefore, we suggest that tumors can arise from multiple cellular states along the cerebellar "lineage of origin".