Type 2 Diabetes Mellitus in a 7 Year Old Girl.
Basma HarisSamuel StafraceKhalid HussainPublished in: International medical case reports journal (2022)
Type 2 diabetes is a chronic disease due to insulin resistance resulting in hyperglycemia. The prevalence of type 2 diabetes is increasing worldwide in the pediatric population. In the pediatric population, type 2 diabetes typically develops around adolescence; however, patients with a younger age of onset are now being reported. Earlier onset of type 2 diabetes is associated with a more aggressive course of disease and earlier comorbidities, although data on this is limited. We report a child from Qatar with type 2 diabetes that was diagnosed at 7 years of age, along obesity with a BMI of 26.8 kg/m 2 . Elevated liver enzymes, c-peptide, and insulin levels were observed along with fatty liver on an ultrasound. The child had severe acanthosis nigricans with increased appetite. There was a positive family history for type 2 diabetes. Testing for type 1 diabetes autoantibodies, monogenic obesity, and monogenic diabetes screening was negative. This is the second youngest child reported to have type 2 diabetes. Accurate diagnosis, early reporting, and long-term follow-up of such cases is necessary to bring more attention to the subgroup of type 2 diabetes in very young patients.
Keyphrases
- type diabetes
- glycemic control
- insulin resistance
- cardiovascular disease
- mental health
- magnetic resonance imaging
- end stage renal disease
- high fat diet
- adipose tissue
- body mass index
- systemic lupus erythematosus
- depressive symptoms
- computed tomography
- risk factors
- clinical trial
- emergency department
- skeletal muscle
- peritoneal dialysis
- early onset
- open label
- prognostic factors
- working memory
- deep learning
- physical activity
- oxidative stress
- middle aged
- body weight
- polycystic ovary syndrome
- drug induced