A Mutated Prostatic Acid Phosphatase (PAP) Peptide-Based Vaccine Induces PAP-Specific CD8 + T Cells with Ex Vivo Cytotoxic Capacities in HHDII/DR1 Transgenic Mice.

Pauline Le VuJayakumar VadakekolathuSarra IdriHolly NichollsManon CavaignacStephen ReederMasood A KhanDennis ChristensenAlan Graham Pockley Stéphanie E B McArdle

Published in: Cancers (2022)

The periphery of patients with PCa exhibits immune responsiveness to the MutPAP42mer peptide and immunization of mice induces/expands T cell-driven, wild-type PAP immunity, and therefore, has the potential to drive protective anti-tumor immunity in patients with PCa.

Keyphrases

wild type
prostate cancer
radical prostatectomy
human health
risk assessment
adipose tissue
metabolic syndrome
editorial comment
high fat diet induced
insulin resistance