Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization.

Francesca FasoloHong Jin Greg WinskiEkaterina ChernogubovaJessica Pauli Hanna WinterDaniel Y LiNadiya GlukhaSabine BauerSusanne MetschlZhiyuan WuMarlys L KoschinskyMuredach P ReillyJaroslav PelisekWolfgang KempfHans-Henning Eckstein Oliver Soehnlein Ljubica Matic Ulf HedinAlexandra BäcklundClaes BergmarkValentina Paloschi Lars Maegdefessel

Published in: Circulation (2021)

The lncRNA MIAT is a novel regulator of cellular processes in advanced atherosclerosis that controls proliferation, apoptosis, and phenotypic transition of SMCs, and the proinflammatory properties of macrophages, as well.

Keyphrases

long noncoding rna
oxidative stress
coronary artery disease
endoplasmic reticulum stress
cardiovascular disease
signaling pathway
cell death
transcription factor
cell cycle arrest
long non coding rna
type diabetes
cell proliferation