Influence of PEGylation on PLGA nanoparticle properties, hydrophobic drug release and interactions with human serum albumin.

The ability to fine tune drug release and formation of protein corona around nanoparticles is crucial to formulation scientists. This study suggests that PLGA NPs with low PEG content might be suitable for extended circulation and rapid drug release and that higher PEG content retards hydrophobic drug release.