Apoptotic and Anti-metastatic Effects of Atractylodes lancea (Thunb.) DC. in a Hamster Model of Cholangiocarcinoma.
Paradon SonsomnuekMayuri TarasukTullayakorn PlengsuriyakarnKanyarat BoonprasertKesara Na-BangchangPublished in: Asian Pacific journal of cancer prevention : APJCP (2022)
The anti-CCA activity of AL in OV/DMN-induced CCA hamsters could be due to the induction of cell cycle arrest at the G1 phase and activation of the apoptosis pathway, resulting in cancer cell death. The activation of the apoptosis pathway mainly involved the intrinsic pathway (activation of caspase-3 and caspase-9 through p53 and Mfge-8 modulation and downregulation of anti-apoptotic genes Akt and Bcl-2). In addition, AL could also inhibit the canonical TGF-β signaling pathway, MMP-9 and N-cadherin to suppress tumor metastasis.
Keyphrases
- cell death
- cell cycle arrest
- signaling pathway
- pi k akt
- cell proliferation
- small cell lung cancer
- papillary thyroid
- squamous cell carcinoma
- epithelial mesenchymal transition
- induced apoptosis
- genome wide
- oxidative stress
- dna methylation
- transforming growth factor
- squamous cell
- endoplasmic reticulum stress
- drug induced
- genome wide identification
- cell adhesion
- genome wide analysis