Biomarkers of Cartilage Composition.
Maximilian T LöfflerZehra AkkayaRupsa BhattacharjeeThomas M LinkPublished in: Seminars in musculoskeletal radiology (2024)
Magnetic resonance imaging (MRI) has significantly advanced the understanding of osteoarthritis (OA) because it enables visualization of noncalcified tissues. Cartilage is avascular and nurtured by diffusion, so it has a very low turnover and limited capabilities of repair. Consequently, prevention of structural and detection of premorphological damage is key in maintaining cartilage health. The integrity of cartilage composition and ultrastructure determines its mechanical properties but is not accessible to morphological imaging. Therefore, various techniques of compositional MRI with and without use of intravenous contrast medium have been developed. Spin-spin relaxation time (T2) and spin-lattice relaxation time constant in rotating frame (T1rho) mapping, the most studied cartilage biomarkers, were included in the recent standardization effort by the Quantitative Imaging Biomarkers Alliance (QIBA) that aims to make compositional MRI of cartilage clinically feasible and comparable. Additional techniques that are less frequently used include ultrashort echo time with T2*, delayed gadolinium-enhanced MRI of cartilage (dGEMRIC), glycosaminoglycan concentration by chemical exchange-dependent saturation transfer (gagCEST), sodium imaging, and diffusion-weighted MRI.
Keyphrases
- contrast enhanced
- diffusion weighted
- magnetic resonance imaging
- high resolution
- magnetic resonance
- diffusion weighted imaging
- extracellular matrix
- computed tomography
- single molecule
- healthcare
- public health
- room temperature
- density functional theory
- gene expression
- low dose
- mental health
- knee osteoarthritis
- mass spectrometry
- risk assessment
- bone mineral density
- real time pcr