Comparative Proteome Analysis of Epicardial and Subcutaneous Adipose Tissues from Patients with or without Coronary Artery Disease.
Yu Xing ZhaoHui-Juan ZhuHui PanXue Mei LiuLin Jie WangHong Bo YangNai Shi LiFeng Ying GongWei SunYong ZengPublished in: International journal of endocrinology (2019)
The largest profiles of differentially expressed proteins in EAT and SAT between CAD patients and non-CAD patients were identified. The significant signal pathways, mitochondrial dysfunction, and LXR/RXR activation, which differential proteins were involved in, were firstly found to play roles in EAT of CAD patients, and clusterin was firstly found to be upregulated in EAT of CAD patients.
Keyphrases
- coronary artery disease
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- heart failure
- type diabetes
- gene expression
- patient reported outcomes
- percutaneous coronary intervention
- metabolic syndrome
- skeletal muscle
- insulin resistance
- aortic stenosis