DNA methylation and gene expression of TXNIP in adult offspring of women with diabetes in pregnancy.

Azadeh Houshmand-OeregaardLine HjortLouise KelstrupNinna S HansenChrista BroholmLinn GillbergTine D ClausenElisabeth R MathiesenPeter DammAllan Vaag

Published in: PloS one (2017)

We found no evidence of decreased TXNIP DNA methylation or increased gene expression in metabolic target tissues of offspring exposed to maternal diabetes. Further studies are needed to confirm and understand the paradoxical SAT TXNIP DNA methylation and gene expression changes in O-GDM subjects.

Keyphrases

gene expression
dna methylation
nlrp inflammasome
genome wide
type diabetes
cardiovascular disease
high fat diet
glycemic control
pregnancy outcomes
copy number
physical activity
insulin resistance
weight loss
body mass index
case control