Pharmacological Npt2a Inhibition Causes Phosphaturia and Reduces Plasma Phosphate in Mice with Normal and Reduced Kidney Function.

Linto ThomasJianxiang XueSathish Kumar MuraliRobert A FentonJessica A Dominguez RiegTimo Rieg

Published in: Journal of the American Society of Nephrology : JASN (2019)

Npt2a inhibition causes a dose-dependent increase in phosphate, sodium and chloride excretion associated with reductions in plasma phosphate and PTH levels in normal mice and in a CKD mouse model.

Keyphrases

mouse model
high fat diet induced
chronic kidney disease
metabolic syndrome
adipose tissue
skeletal muscle