Donor surfactant protein A2 polymorphism and lung transplant survival.

Frank D'OvidioJoanna FlorosBeatrice AraminiDavid J LedererSusan L DiAngeloSelim ArcasoyJoshua R SonettHillary RobbinsLory ShahJoseph CostaAndreacarola Urso

Published in: The European respiratory journal (2020)

Donor lung SP-A gene polymorphisms are associated with post-transplant clinical outcome. Lungs from donors with the SP-A2 variant 1A1 had a reduced survival at 1 year. The observed donor genetic differences, via innate immunity relate to the post-transplant clinical outcome.

Keyphrases

free survival
genome wide
gene expression
protein protein
dna methylation
amino acid
small molecule
copy number