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Outcomes and clinical implications of intranasal insulin on cognition in humans: A systematic review and meta-analysis.

Sally WuNicolette StogiosMargaret HahnJanani NavagnanavelZahra EmamiAraba ChintohPhilip GerretsenAriel Graff-GuerreroTarek K RajjiGary RemingtonSri Mahavir Agarwal
Published in: PloS one (2023)
This review demonstrates that INI may be associated with pro-cognitive benefits for global cognition, specifically for individuals with AD/MCI. Further studies are required to better understand the neurobiological mechanisms and differences in etiology to dissect the intrinsic and extrinsic factors contributing to the treatment response of INI.
Keyphrases
  • mild cognitive impairment
  • type diabetes
  • white matter
  • glycemic control
  • anti inflammatory
  • case control
  • metabolic syndrome
  • insulin resistance