Efficiency of riboflavin and ultraviolet light treatment against high levels of biofilm-derived Staphylococcus epidermidis in buffy coat platelet concentrates.

M TahaB CulibrkM KalabP SchubertQ-L YiR GoodrichSandra Ramirez-Arcos

Published in: Vox sanguinis (2017)

Riboflavin-UV treatment was similarly efficacious in PCs produced from WB inoculated with S. epidermidis biofilm or non-biofilm cells. Levels of biofilm-derived S. epidermidis ≥103 CFU/ml were not completely inactivated; however, further testing is necessary with lower (real-life) bacterial levels.

Keyphrases

biofilm formation
staphylococcus aureus
pseudomonas aeruginosa
candida albicans
escherichia coli
induced apoptosis
oxidative stress
combination therapy