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A catalyst-free method for the synthesis of 1,4,2-dithiazoles from isothiocyanates and hydroxylamine triflic acid salts.

Zhenyu AnTing WangYafeng LiuYi RenRulong Yan
Published in: Organic & biomolecular chemistry (2022)
A catalyst-free method for the preparation of 1,4,2-dithiazoles is developed by reactions of isothiocyanates with hydroxylamine triflic acid salts. This reaction achieves C-S, C-N, and S-N bond formation, and a range of products are obtained in moderate to good yields. The obvious feature is using shelf-stable hydroxylamine triflic acid salts as a N source to synthesize heterocycles under mild conditions.
Keyphrases
  • ionic liquid
  • room temperature
  • highly efficient
  • machine learning
  • deep learning
  • mass spectrometry
  • liquid chromatography