Plasma extrachromosomal circular DNA is a pathophysiological hallmark of short-term intensive insulin therapy for type 2 diabetes.
Zhe XuJunyu HePeng HanPeiji DaiWei LvNian LiuLiyi LiuLiehua LiuXiaoguang PanXi XiangHanbo LiFangfang GeShan GaoZhihong LiaoYonglun LuoYanbing LiPublished in: Clinical and translational medicine (2023)
This study represents the first report of cell-free eccDNA in T2DM and underscores a compelling association between cell-free eccDNA and profound glycemic changes. These findings highlight the potential of eccDNAs as crucial players in the context of T2DM and glycemic control.