Rhodium-Catalyzed Synthesis of Unsymmetric Di(heteroaryl)ureas Involving an Equilibrium Shift.

Mieko ArisawaTaro MizunoKanako Nozawa-KumadaKaori Itto-NakamaMiyu FurutaSaori Tanii

Published in: Organic letters (2021)

Unsymmetric di(heteroaryl)ureas such as HetAr1-NHCONH-HetAr2 are efficiently synthesized from two symmetric ureas, HetAr1-NHCONH-HetAr1 and HetAr2-NHCONH-HetAr2, by rhodium-catalyzed exchange reactions. The equilibrium in some of the reactions can be shifted to the formation of unsymmetric ureas by the aggregation of the dimers formed by inter- and intramolecular hydrogen bonding.

Keyphrases

molecular dynamics
room temperature
molecular dynamics simulations
biofilm formation
pseudomonas aeruginosa
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energy transfer
quantum dots