Clinical assessment of endothelial function in convalescent COVID-19 patients: a meta-analysis with meta-regressions.
Pasquale AmbrosinoStefano Sanduzzi ZamparelliMarco MosellaRoberto FormisanoAntonio MolinoGiorgio Alfredo SpedicatoAntimo PapaRosanna CapparelliMatteo Nicola Dario Di MinnoMauro ManiscalcoPublished in: Annals of medicine (2022)
Impaired endothelial function can be documented in convalescent COVID-19 patients, especially when residual clinical manifestations persist. Targeting endothelial dysfunction through pharmacological and rehabilitation strategies may represent an attractive therapeutic option.Key messagesThe mechanisms underlying the post-acute sequelae of coronavirus disease 2019 (COVID-19) have not been fully elucidated.Impaired endothelial function can be documented in convalescent COVID-19 patients for up to 1 year after infection, especially when residual clinical manifestations persist.Targeting endothelial dysfunction may represent an attractive therapeutic option in the post-acute phase of COVID-19.