Decreased cyclooxygenase-2 associated with impaired megakaryopoiesis and thrombopoiesis in primary immune thrombocytopenia.
Xibing ZhuangPengcheng XuYang OuXia ShaoYing LiYanna MaShanshan QinFanli HuaYanxia ZhanLili JiTiankui QiaoHao ChenYunfeng ChengPublished in: Journal of translational medicine (2023)
COX-2 plays a vital role in the physiologic and pathologic conditions of ITP by intervening the survival of platelets and impairing the megakaryopoiesis and thrombopoiesis of megakaryocytes.