Intravesical Oncolytic Virotherapy and Immunotherapy for Non-Muscle Invasive Bladder Cancer Mouse Model.

Woodson W SmelserJian WangKristen M OgdenSam S ChangAustin N Kirschner

Published in: BJU international (2023)

Treatment of murine orthotopic bladder tumors with a single instillation of intravesical reovirus, anti-PD-1 antibody, or the combination confers superior survival compared to controls. Tumor-immune microenvironment differences indicated myeloid-derived suppressor cells and CD8+ T cells mediate the treatment response.

Keyphrases

muscle invasive bladder cancer
mouse model
induced apoptosis
stem cells
cell cycle arrest
spinal cord injury
urinary tract
signaling pathway