Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight.
J Sebastian Garcia-MedinaKarolina SienkiewiczS Anand NarayananEliah G OverbeyKirill GrigorevKrista A RyonMarissa BurkeJacqueline ProszynskiBraden TierneyCaleb M SchmidtNuria Mencia-TrinchantRemi KlotzVeronica OrtizJonathan FooxChristopher ChinDeena NajjarIrina MateiIrenaeus C C ChanCarlos CruchagaAshley KleinmanJangKeun KimAlexander LucaciConor LoyOmary MzavaIwijn De VlaminckAnvita SingarajuLynn E TaylorJulian C SchmidtMichael A SchmidtKelly BleaseJuan MorenoAndrew BoddickerJunhua ZhaoBryan LajoieAndrew AltomareSemyon KruglyakShawn LevyMin YuDuane C HassaneSusan M BaileyKelly BoltonJaime MateusChristopher E MasonPublished in: Precision clinical medicine (2024)
Our findings provide valuable insights into the physiological consequences of short-duration spaceflight, with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to Earth. CHIP sequencing data will serve as a reference point for studying the early development of CHIP in astronauts, an understudied phenomenon as previous studies have focused on career astronauts. This study will serve as a reference point for future commercial and non-commercial spaceflight, low Earth orbit (LEO) missions, and deep-space exploration.