α-synuclein (SNCA) but not dynamin 3 (DNM3) influences age at onset of leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease in Spain.
Rubén Fernández-SantiagoAlicia GarridoJon InfanteIsabel González-AramburuMaría SierraManel FernándezFrancesc ValldeoriolaEsteban MuñozYaroslau ComptaMaría-José MartíJosé RíosEduardo TolosaMario Ezquerranull nullPublished in: Movement disorders : official journal of the Movement Disorder Society (2018)
Our results indicate that SNCA rs356219 but not dynamin 3 DNM3 rs2421947 modifies the penetrance of the mutation G2019S in the Spanish population by influencing the L2PD age at onset. These findings suggest that different genetic modifiers may influence the L2PD age at onset in different populations. © 2018 International Parkinson and Movement Disorder Society.