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Evaluation of tramadol human pharmacokinetics and safety after co-administration of magnesium ions in randomized, single- and multiple-dose studies.

Piotr Józef RudzkiKatarzyna Jarus-DziedzicMonika FilistEdyta GilantKatarzyna Buś-KwaśnikAndrzej LeśMałgorzata Sasinowska-MotylŁukasz NagrabaMagdalena Bujalska-Zadrożny
Published in: Pharmacological reports : PR (2021)
The absence of Mg2+ interaction with tramadol pharmacokinetics and safety suggests that this combination may be used in the clinical practice for the pharmacotherapy of pain.
Keyphrases
  • clinical practice
  • endothelial cells
  • chronic pain
  • double blind
  • open label
  • pain management
  • neuropathic pain
  • smoking cessation
  • clinical trial
  • placebo controlled
  • induced pluripotent stem cells
  • study protocol