FFPE breast tumour blocks provide reliable sources of both germline and malignant DNA for investigation of genetic determinants of individual tumour responses to treatment.
Anna WilkinsRitika ChauhanAlistair RustAlex PearsonFrances DaleyFloriana ManodoroKerry FenwickJudith BlissJohn YarnoldNavita SomaiahPublished in: Breast cancer research and treatment (2018)
There is good correlation between the somatic mutations and CNA called using archived blood or normal breast tissue as germline reference material.